Heart disease
Individuals with no known risk factors can have underlying heart disease. If the heart function deteriorates when challenged with exercise, it is an indication of underlying heart disease. Exercise capacity measured by CPET (peak VO2) can be used to accurately stratify the risk and can help initiate more aggressive treatment well before patients develop symptoms.
One of the unique advantages of CPET is the ability to evaluate the benefit of intervention through serial measurement of exercise capacity by measuring peak VO2, and compare the improvement in peak VO2 from baseline value.